The preparation of aspirin: page 2 of 2 p h o toco p y p chemical tests for purity the addition of a chemical reagent to identify substances is a common procedure in chemical analysis often the reagent added forms a coloured compound with the substance under investigation in this experiment iron(iii) ions react. Experiment 8 – synthesis of aspirin aspirin is an effective analgesic (pain reliever), antipyretic (fever reducer) and anti-inflammatory agent and is one of the most widely used non-prescription drugs the use of aspirin had its origin in the 18th century, when it was found that an extract from the bark of willow trees was useful. Synthesis of acetylsalicylic acid by the german chemist felix hoffmann in 1893 your two primary objectives in this experiment will be to synthesize and analyze aspirin there is more than one way to synthesize aspirin in this experiment, you will react acetic anhydride with salicylic acid in the presence of phosphoric acid. Experiment: synthesis of aspirin background “aspirin, which ranks as the most widely used drug in the united states, is one of a series of salicylic acid esters that has been known since antiquity to have therapeutic effects in fact, many cultures have used plants containing significant amounts of these compounds in. To synthesize aspirin from salicylic acid, test for the purity of the product obtained, and determine the number of aspirin tablets that can be obtained from your handle it carefully to avoid contact with skin and clothing methanol is toxic breathing its vapors and skin contact with methanol should be avoided procedure. In this experiment you will synthesize aspirin (acetylsalicylic acid, c9h8o4 ), purify it, and determine the percent yield the purity of the product will be confirmed by qualitative analysis and by measuring its melting point range the reaction that is used for the synthesis is shown below in this reaction, an excess of acetic.
To download a student copy of the lab handout, click the link to the file at the bottom of this page laboratory exercise: synthesis of a drug background: in this lab, you are going to synthesize a very popular and widely used medicinal drug, aspirin (acetylsalicylic acid) aspirin is actually a naturally. Get an answer for 'for the synthesis of aspirin, how do you calculate the percent yield if the reaction produces 470 grams of aspirin the reaction, using molecular formulas is c7h6o3 + c4h6o3 -- c9h8o4 + c2h4o2 the relevant molecular weights are 180 grams per mole for aspirin, and 138 grams per mole for salicylic. Learn how to synthesize aspirin from salicylic acid get information about the effects of salicylates, and see the structures of the reactants. Aspirin synthesis and analysis revised: 12/13/14 cooled to freeze) in this experiment, you will measure the melting point of your synthesized asa product, salicylic acid, a crushed aspirin tablet, and pure asa from a manufacturer • samples with unreacted salicylic acid complex with fe3+ to create a.
View notes - synthesis of aspirin from chemistry 254 at ohio state synthesis of aspirin name: mohammed muntaser teaching assistant: nathan line lab: t/r 2:30 pm 410 ce submitted: may 3. Warnings caution - to be used under adult supervision proper laboratory safety procedures should always be followed chemical - for lab use only not recommended for food, drug or cosmetic use chemical - please refer to the included msds sheet for more information about safety chemical - this is a chemical. Synthesis of aspirin lab report 3004 words mar 18th, 2014 13 pages abstract: the goal of this experiment was to synthesize aspirin in this experiment aspirin, also known as acetylsalicylic acid, was synthesized from salicylic acid and acetic anhydride in the reaction the hydroxyl group on the benzene ring in salicylic.
Analgesics are compounds used to reduce pain, antipyretics are compounds used to reduce fever one popular drug that does both is aspirin. The documented rf for pure aspirin is 0 56 however this experiment shows pure aspirin to be 0 95, therefore for the purpose of comparison the documented value shall be used this could be due to contamination, incorrect processes in the procedure, the amount of solution used or the temperature of the solution,. Experiment, phosphoric acid will be used as the catalyst the excess acetic acid will be quenched with the addition of water the aspirin product is not very soluble in water so the aspirin product will precipitate when water is added the synthesis reaction of aspirin is shown below: since acetic acid is very soluble in water,.
This is the procedure for a fe(iii) catalyzed synthesis of aspirin, an alternative to the traditionally sulfuric acid catalyzed synthesis of aspirin the prep compares and contrasts the bronsted acid catalyzed esterification reaction with a lewis acid iron (iii) catalyzed pathway this can be used in different courses. Synthesis of aspirin in this experiment, aspirin will be made by the esterification of salicylic acid the product will be isolated and a thin layer chromatography ( tlc) will be used to analyze the success of the reaction procedure for two different reactions scales microscale and mini-scale are provided.